Consultant in Paediatric Immunology & Bone Marrow Transplantation
Great Ormond Street Hospital, London
Some children are born with defective immune systems and have problems dealing with infections, or develop abnormal responses causing inflammation and autoimmunity. The genetic basis of many of these conditions can now be determined using a combination of gene screening tests and assays to determine immune cell phenotype and function
Bone & Blood Stem Cell Transplants
Where defects of the immune system lead to serious complications, bone marrow transplantation is often considered. Stem cells can be collected from bone marrow, from peripheral blood and from umbilical cord blood. A well matched donor ( a HLA matched sibling) is the preferred choice, but with improved techniques, unrelated donor and mismatched transplants are also widely used. We are developing approaches to limit complications such as graft versus host and disease and virus infections.