Genome editing 

Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9 genome editing tools, as well as older versions based on Zinc Finger Nucleases (ZFNs) and TALE nucleases (TALENS) are being investigated. In some cases, we have generated hybrid lentiviral vectors for CRISPR delivery and expect these to be particularly useful for CAR-T cell engineering. Similar tools are being used to ‘base-edit’ genes to chemically create single base pair changes without the need for DNA breaks. Our goal is to identify and advance the most promising technologies into clinical phase testing.